Electrophysiologic actions of mexiletine (Kö-1173) in man
González Maqueda, I.; García Fernández, F.; Martín Jadraque, L.
Medicina Clinica 76(5): 223-225
1981
ISSN/ISBN: 0025-7753 PMID: 7206892 Document Number: 173462
Electrophysiologic studies were performed in 11 patients before and 12 min after i.v. administration of 250 mg of mexiletine. All patients had crisis of paroxysmal tachycardia. The cases with conduction defects at any level, as ascertained by surface ECG or basal electrophysiologic recordings, were excluded from treatment. The results obtained do not show significant variations in any of the parameters studied. Mexiletine is an antiarrhythmic drug with an action typical of group I of the classification of Vaughan Williams, it reduces the maximum velocity of systolic depolarization. In the absence of conduction defects, its behavior is similar to that of lidocaine or diphenylhydantoin.