Evaluation of the quality of mexiletine hydrochloride using capillary electrophoreses
Proksa, B.; Proksová, A.
Ceska a Slovenska Farmacie Casopis Ceske Farmaceuticke Spolecnosti a Slovenske Farmaceuticke Spolecnosti 49(4): 195-198
2000
ISSN/ISBN: 1210-7816 PMID: 10953471 Document Number: 512593
Mexiletine hydrochloride and its potential impurity xylenol were determined by micellar electrokinetic chromatography in a 25 cm long capillary. The effect of parameters--temperature, electric field, concentration of analyzed compounds, type and composition of background electrolyte--on the separation of analytes and precision of analysis was studied. The advantage of the elaborated method is a very short time of analysis (2.3 min) at the sufficient level of precision and reliability of results.