Comparative evaluation of chronic estrone toxicity when administered by different routes
Marinina, T.F.; Shapiro, B.M.; Murav'ev, I.A.
Farmakologiia i Toksikologiia 44(1): 117-121
1981
ISSN/ISBN: 0014-8318 PMID: 7262294 Document Number: 172927
The paper concerns the results of studying chronic toxicity of estrone injected subcutaneously in the form of oily solution and vaginal suppositoria prepared on the basis of vitepsol. It has been shown that subcutaneous administration of the drug for 2 months results in dystrophic alterations in the liver, these alterations being more pronounced than those induced by intravaginal administration of estrone in the form of suppositoria.
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