Bilirubin binding and neonatal acidosis
Perlman, M.; Kapitulnik, J.; Blondheim, S.H.; Alayoff, A.; Russell, A.
Clinical Chemistry 27(11): 1872-1874
1981
ISSN/ISBN: 0009-9147 PMID: 7296838 Document Number: 172112
Plasma of neonates with severe metabolic acidosis secondary to fetal hypoxia bound less bilirubin than that of neonates without acidosis, as determined by Sephadex gel filtration. There was a significant correlation between the amount of bilirubin adsorbed by Sephadex and the base deficit. The method used ruled out any influence of plasma pH per se on binding. Our results suggest that organic anions that accumulate in the plasma of asphyxiated acidotic neonates may compete with bilirubin for binding sites on albumin.