Lichenoid Dermatitis from Interferon alpha-2a in a Patient with Metastatic Renal Cell Carcinoma and Seronegative HCV
Bush, A.E.; Hymes, S.R.; Silapunt, S.
Journal of Drugs in Dermatology Jdd 16(7): 714-716
2017
ISSN/ISBN: 1545-9616 PMID: 28697228 Document Number: 17178
Cutaneous reactions to interferon, including a lichenoid drug reaction, are most commonly reported in patients undergoing treatment for hepatitis C virus (HCV) infection. There have been case reports of interferon-induced lichen planus in seronegative HCV patients with lymphoproliferative disorders and melanoma. We report the case of a 71-year-old man undergoing treatment with interferon for metastatic renal cell carcinoma (RCC) who developed an eruption 2 months after starting interferon. Clinical and histological findings from biopsies supported a diagnosis of interferon-induced lichen planus. To our knowledge, this is the first known case of a lichenoid drug eruption from interferon in a seronegative HCV patient with metastatic RCC.
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