Gluten-sensitive enteropathy. I. The T-dependent anti-A-gliadin antibody response maps to the murine major histocompatibility locus

Trefts, P.E.; Kagnoff, M.F.

Journal of Immunology 126(6): 2249-2252

1981


ISSN/ISBN: 0022-1767
PMID: 6971892
Document Number: 171751
The genetic control of the murine humoral immune response to purified A-gliadin, a protein derived from wheat gluten, which is known to cause small intestinal disease in susceptible individuals was examined. Studies with congenic and noncongenic inbred strains of mice revealed that the thymus-dependent humoral immune response to A-gliadin is under the control of genes mapping to the mouse major histocompatibility complex. These findings in mice establish a clear linkage between the MHC and the regulation of the immune response to a protein capable of causing human disease.

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