Factors that control stem cell differentiation. II. the sensitivity of T-differentiated lymphocytes to the action of radiation and cytostatics
Man'ko, V.M.; Saiadian, K.S.; Khalatian, N.A.
Tsitologiia 23(3): 333-339
1981
ISSN/ISBN: 0041-3771 PMID: 6972648 Document Number: 171527
Bone marrow stem cells of the parent genotype (CBA) produce mainly erythroid colonies in the spleen of lethally irradiated recipients (CBA-C57Bl)F1. T d-lymphocytes change this differentiation pattern from the mainly erythroid to the mainly myeloid pathway. The irradiation with 100 R does not abolish this effect. The lymphocytes irradiated in vitro with 200 R or more, and incubated with Mitomycin C or Cycloheximide lost the ability to change the differentiation pattern of the transplanted cells. T d-lymphocytes are radiosensitive cells that need DNA and protein synthesis for realizing their function.