Examining HIV Viral Load in a Matched Cohort of HIV Positive Individuals with and Without Psoriasis

Wu, J.J.; Gilbert, K.E.; Batech, M.; Manalo, I.F.; Towner, W.J.; Raposo, R.A.é S.; Nixon, D.F.; Liao, W.

Journal of Drugs in Dermatology Jdd 16(4): 372-377

2017


ISSN/ISBN: 1545-9616
PMID: 28403272
Document Number: 17138
BACKGROUND: HIV-associated psoriasis is well-documented. Genetic, cellular, and cytokine profiles have been used as evidence to suggest psoriasis activates antiviral pathways. There has been a lack of epidemiologic evidence investigating whether psoriasis patients have lower HIV viral counts compared to non-psoriasis patients. OBJECTIVE: Compare the viral load set point of HIV positive patients with and without psoriasis. METHODS: A retrospective matched cohort study of HIV positive patients with and without psoriasis using the Kaiser Permanente Southern California Health Plan database. RESULTS: We identified 101 HIV-positive psoriasis cases; 19 met inclusion criteria and were matched with 3-5 control patients; 94 total patients were analyzed. The mean age was 41.4 (12.07) years and 83% were male. Overall, the median log of the viral load of cases was slightly higher than controls (4.3 vs 4.2; P less than 0.01). CONCLUSIONS: The serum viral load set point of patients with HIV and psoriasis was slightly higher than the viral load set point of HIV patients without psoriasis.

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Examining HIV Viral Load in a Matched Cohort of HIV Positive Individuals with and Without Psoriasis