Effect of Curcumin on Characterization and Localization of Interleukin-13 and Tumor Necrosis Factor-alpha in Liver of Diabetic Rats
Satin, K.; Petpiboolthai, H.; Anupunpisit, V.
Journal of the Medical Association of Thailand 99(Suppl 8): S187-S195
2016
ISSN/ISBN: 0125-2208 PMID: 29906037 Document Number: 17130
To localize and characterize inflammatory markers: interleukin-13 (IL-13) and Tumor necrosis factor-alpha (TNF-alpha) in recovery livers after curcumin supplementation in streptozotocin-induced diabetic rats. Induced diabetic male rats were achieved by streptozotocin intravenous injection (50 mg/kg BW). The rats were divided into three groups, control rat (C), diabetic rat (DM) and diabetic rat supplemented with curcumin According DM group, high intensity of IL-13 and TNF-alpha were accumulated around central vein, along hepatic parenchyma, and at perivascular sinusoidal areas. In contrast, the characterization of IL-13 and TNF-alpha in DMC were attenuated. Then, the liver tissues were recovered and engaged by less severity sign of inflammations. Therefore, dietary curcumin might have efficacy to ameliorate diabetic complications in terms of controlling and modulating inflammatory parameters, including IL-13, and TNF-alpha. Administration of curcumin successfully attenuated liver tissue by means of decreased inflammatory cytokine markers. The potential beneficial effects of curcumin have been shown to decline the inflammatory of liver tissue, concerning illustration of IL-13, and TNF-alpha. Therefore, the efficiency and achievement of curcumin might be applied to be an alternative therapeutic agent in diabetic liver.