Skin pathology following epicutaneous exposure to seven organic solvents
Kronevi, T.; Wahlberg, J.E.; Holmberg, B.
International Journal of Tissue Reactions 3(1): 21-30
1981
ISSN/ISBN: 0250-0868 PMID: 7026421 Document Number: 171254
1,1,1,-Trichloroethane, benzene, trichloroethylene, tetrachloroethylene, dibromoethane, 1,2-dichloroethane, and 1,1,2,2-tetrachloroethane were applied to the skin of guinea-pigs for histopathological studies. Biopsies taken at different times of exposure showed the presence of karyopyknosis for all solvents tested; 1,1,1-trichloroethane, benzene, trichloroethylene, and tetrachloroethylene showed karyolysis; 1,1,1-trichloroethane, benzene, trichloroethylene, tetrachloroethylene, and dichloroethane induced spongiosis. All solvents, except 1,1,2,2-tetrachloroethane, produced junctional separation. Pseudoeosinophilic infiltration occurred for all solvents, except for 1,2-dichloroethane. The results are discussed in terms of occupational hazards and in relation to parallel studies on blood uptake and systemic toxicity at epicutaneous administration.