Diuretics and uric acid
Ben Maiz, H.; Kheder, A.; Kouki, F.; Safar, M.; Ben Ayed, H.; Milliez, P.
La Semaine des Hopitaux Organe Fonde Par l'Association d'Enseignement Medical des Hopitaux de Paris 57(47-48): 1987-1991
1981
ISSN/ISBN: 0037-1777 PMID: 6276979 Document Number: 170879
Long-term diuretic therapy often increases serum uric acid. The renal metabolism of uric acid is recalled and the factors which lead to diuretic-induced hyperuricemia are discussed. Fluid and sodium loss appears to be the main cause of increased serum uric acid. The authors' experience with management of severe hypertension is consistent with this theory. The effect of tienilic acid which lowers serum uric acid levels is discussed.