Quantitative estimation of potentiating or inhibitory effects of similarly acting drugs in combination. Advantages of a dose-response curve method over the isoboles-method
Pöch, G.
Arzneimittel-Forschung 31(7): 1135-1140
1981
ISSN/ISBN: 0004-4172 PMID: 7196763 Document Number: 170703
Experimental effects of two synergistically acting drugs in combination can be compared with theoretical additive effects by means of various methods. In this paper a new method has been extended and analyzed for its advantages over the isoboles method. The main advantages of the new method are the simplicity of the experimental technique of combination-experiments, the evaluation in terms of dose-response curves and the adequate quantitative determination of non-additive combination effects. The method allows the evaluation of the mode of action of effects brought about in combination, e.g., in functional and sequential potentiation.