Protection of neonatal mice against herpes simplex viral infection by human antibody and leukocytes from adult, but not neonatal humans
Kohl, S.; Loo, L.S.; Pickering, L.K.
Journal of Immunology 127(4): 1273-1275
1981
ISSN/ISBN: 0022-1767 PMID: 7276559 Document Number: 169787
Neither human immune globulin nor human mononuclear leukocytes (containing lymphocytes and monocytes) from herpes simplex virus (HSV) seronegative adult donors could protect infant C57BL/6 mice from a lethal HSV infection. In contrast, a combination of 5 X 10(6) leukocytes and a subneutralizing dose of antibody protected the mice. Leukocytes (5 X 10(6) or 1 X 10(7)) from neonatal humans and antibody could not mediate this protection. This is the first correlation between defective human neonatal leukocyte antibody-dependent cellular cytotoxicity (ADCC) in vitro and defective human neonate leukocyte-antibody protection against HSV infection in vivo in mice.