Evidence for histamine and 5-hydroxytryptamine like effects of MK-212 on guinea pig ileum, taenia coli and rat fundus strip
Patel, U.P.; Verma, S.C.
Indian Journal of Physiology and Pharmacology 25(4): 379-384
1981
ISSN/ISBN: 0019-5499 PMID: 6122646 Document Number: 169515
MK-212 receptor antagonist. Mepyramine (1 .times. 10-8 M)-H1 receptor antagonist also inhibited competitively the responses of guinea pig ileum and tenia coli to MK-212. It failed to block significantly the responses of rat fundus strip to MK-212. Metiamide (1 .times. 10-6 M), propranolol (1 .times. 10-6 M) or atropine (1 .times. 10-6 M) did not produce any significant effects on MK-212 induced contractile responses of guinea pig ileum, tenia coli and rat fundus strip. Evidently, MK-212 produces both 5-HT- and histamine-like effects on the guinea pig ileum, tenia coli and rat fundus strip.