Male pseudohermaphroditism. State and present problems
Jambart, S.; Hamon, P.; de Gennes, J.L.
La Semaine des Hopitaux Organe Fonde Par l'Association d'Enseignement Medical des Hopitaux de Paris 57(13-14): 717-724
1981
ISSN/ISBN: 0037-1777 PMID: 6264624 Document Number: 169170
Male phenotypic sexual development in the human fetus is described as follows: transformation of the undifferentiated gonad into testis under the HY antigen influence; testicular secretion of testosterone (which allows the development of the Wolffian ducts derivatives) and of MIF (which inhibits the development of the Mullerian duct); masculinization of the external genitalia under the influence of dihydrotestosterone. Abnormalities [3] which may lead to a male pseudohermaphroditism are outlined as follows: disorders of testicular differentiation, defects of testicular function and androgen insensitiveness at the target areas. Diagnostic steps and therapeutic management are considered, especially in relation to the choice of the sex and the risk of gonadoblastoma.