The Changes in Mean Platelet Volume after Using of Antiplatelet Drugs in Acute Ischemic Stroke: a Randomized Controlled Trial
Haungsaithong, R.; Udommongkol, C.; Nidhinandana, S.; Chairungsaris, P.; Chinvarun, Y.; Suwantamee, J.; Sithinamsuwan, P.
Journal of the Medical Association of Thailand 98(9): 852-857
2015
ISSN/ISBN: 0125-2208 PMID: 26591394 Document Number: 16904
To measure the changes of mean platelet volume (MPV) after using four antiplatelet drugs in acute non-cardioembolic ischemic stroke patients and assess the association of antiplatelets and MPV and stroke outcome. Ischemic stroke survivors with National Institute of Health Stroke Scale (NIHSS) 8 were randomly allocated intofour groups, receiving aspirin, clopidogrel, combined aspirin and dipyridamole, and cilostazol. The change of MPV NIHSS, and modified Rankin Scale (mRS) were recorded at baseline and week 4 in all studied groups. MPV was measured using the standard automated blood test for complete blood count. Twenty-one subjects were included in this study. They comprised of five cases in each antiplatelet group, except for aspirin, which had six subjects. Male was 57%, and hypertension was the most common risk factor (61.9%). Most of participants (76%) had small vessel disease. At 4-week, MPVwas reduced and NIHSS, mRS were improved in every studied group. Clopidogrel sign ficantly reduced NIHSS score (p = 0.003), and it produced the greatest reduction in MPV compared to others. Every type of antiplatelets included in this study reduced MPV NIHSS, and mRS in acute non-cardioembolic stroke patients. Clopidogrel improved NIHSS the most.
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