Dexamethasone and osteonecrosis
Black, K.A.; Khangure, M.S.; Owen, E.T.
Australian and New Zealand Journal of Medicine 11(5): 521-525
1981
ISSN/ISBN: 0004-8291 PMID: 6948545 Document Number: 168490
Cases (4) were reported in whom osteonecrosis followed after Dexamethasone was administered in high dosage for a short time to reduce cerebral and spinal cord edema. Although corticosteroids have been implicated in the development of osteonecrosis, the delay from corticosteroid administration to the development of symptoms (9-30 mo.), with further delay in radiographic changes (9-36 mo.) may result in diagnostic confusion.
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