Influence of normal ageing on mechanism of bone loss in women and men in Bangkok
Chailurkit, L-Or.; Piaseu, N.; Rajatanavin, R.
Journal of the Medical Association of Thailand 85(8): 915-921
2002
ISSN/ISBN: 0125-2208 PMID: 12403213 Document Number: 1681
Age and sex related changes in bone metabolism are of interest in the pathogenesis of osteoporosis. However, most data in the literature were studied in Western countries. In a tropical country, such as Thailand, little is known of vitamin D status and bone remodeling. Thus, the aim of this study was to determine the changes of vitamin D levels and biochemical markers of bone turnover in healthy women and men of various age groups between 20-80 years who were living in Bangkok. From the results, vitamin D levels of various age groups did not alter significantly between men and women except in the sixth decade of women. However, men had higher levels of vitamin D than women. In women, all biochemical markers of bone turnover increased with age, with a sharp increase at the onset of menopause. In contrast, biochemical markers of bone turnover in men gradually declined with advancing age. Conclusion: There was no evidence of vitamin D deficiency in the Bangkok population. Women and men showed different age-related changes in bone metabolism.
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