Chemical ionisation mass fragmentographic measurement of dothiepin plasma concentrations following a single oral dose in man
Crampton, E.L.; Glass, R.C.; Marchant, B.; Rees, J.A.
Journal of Chromatography 183(2): 141-148
1980
ISSN/ISBN: 0021-9673 PMID: 7400272 Document Number: 167830
A method is described for the measurement of the antidepressant drug dothiepin in human plasma. The procedure involves the addition of deuterodothiepin as an internal standard, extraction and measurement by chemical ionization mass fragmentography. The minimum measurable concentration of 0.5 ng/ml enabled the pharmacokinetics of dothiepin in man to be studied after a single oral dose of 75 mg of dothiepin hydrochloride. Unlike other tricyclic antidepressants the apparent half-life of elimination (approximately 24 h) showed very little intersubject variation. The apparent volume of distribution was much more variable and could account for the wide range of steady state concentrations which were found in patients taking dothiepin.