Cold insoluble globulin levels in operative trauma: serum depletion, wound sequestration, and biological activity: an experimental and clinical study
Robbins, A.B.; Doran, J.E.; Reese, A.C.; Mansberger, A.R.
American Surgeon 46(12): 663-672
1980
ISSN/ISBN: 0003-1348 PMID: 7447165 Document Number: 167760
There is a significant depression in serum cold insoluble globulin (CIG) following a single surgical procedure in humans. The CIG depression varied in extent, onset time, and duration so as to make causitive factors unclear. CIG depression is evident at 2 h after surgery, CIG reaches its lowest level at 4 h and then begins to return to normal. Opsonic protein apparently becomes localized in wound tissue, where it may aid reticuloendothelial removal of effete tissue. Peritoneal macrophage assays indicate that sequestered opsonin maintains its biological activity. Cryoprecipitate infusion apparently increases the recovery of patients with wound sepsis.