Plasma cortisol levels after acute administration of baclofen
Morosini, P.P.; Carletti, P.; Ferretti, G.F.; Campanella, N.; Governatori, D.
Bollettino della Societa Italiana di Biologia Sperimentale 56(23): 2428-2431
1980
ISSN/ISBN: 0037-8771 PMID: 7470285 Document Number: 167617
Plasma cortisol levels after acute administration of Baclofen, a Gaba agonist drug, were evaluated in eight healthy volunteer subjects. After 10 mg. of such drug, cortisol levels did not change appreciably. On the contrary after 20 mg. Baclofen elicited a rise in cortisol plasma levels. Baclofen increases striatal levels of dopamine. Therefore it is possible that metabolic effects of the drug are a consequence of increased levels of dopamine.