The effect of viloxazine on drug-induced inhibition of food intake in the rat
Pleece, S.A.; Kirby, M.J.; Redfern, P.H.
Journal of Pharmacy and Pharmacology 32(8): 558-560
1980
ISSN/ISBN: 0022-3573 PMID: 6106693 Document Number: 167255
In male Wistar rats trained to eat their normal daily dietary requirement in 2 h, doese-dependent decreases in food intake were produced by fenfluramine, tiflorex, mazindol and amphetamine. The antidepressant drug viloxazine (Vivalan) alone did not change food intake significantly, nor did the drug prevent the inhibitory effects of mazindol or amphetamine. Complete prevention of the inhibitory effect of fenfluramine was achieved with viloxazine 7.5 mg/kg; viloxazine 40 mg/kg similarly prevented the anorectic action of tiflorex. An interaction involving 5-hydroxytryptaminergic mechanisms is suggested and as viloxazine given after fenfluramine or tiflorex produced no reversal of the inhibition of food intake, it is suggested that viloxazine prevents access of the anorectic agents to their site of action. The clinical significance of those interactions is discussed.