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Prevention by cimetidine of duodenal ulcer relapses: a multicenter controlled trial

Bader, A.P.; Morin, T.; Druguet, M.; Lambert, R.; Dupuy, P.; Bétourné, C.

Gastroenterologie Clinique et Biologique 4(3): 188-193

1980

ISSN/ISBN: 0399-8320
PMID: 6991351
Document Number: 166634
A double-blind controlled trial compared cimetidine (a single daily dose of 400 mg at bed time for a maximal duration of 12 mo.) to placebo in the prevention of duodenal ulcer relapses. Patients (52) of the cimetidine-group and 39 patients of the placebo-group were kept for analysis. Better results were obtained in the 1st group. Among the patients receiving cimetidine, the number of symptomatic relapses were significantly less (9 or 17.3% as compared to 27 or 69.2% P < 0.001), the delay of recurrence was longer (7.7 mo. as compared to 4.3: P < 0.001), and the actuarial rate of asymptomatic patients was higher (77.5% as compared to 23.5%: P < 0.0001). Relapses were revealed by complications in 1 patient of the cimetidine-group and in 3 patients of the placebo-group. Asymptomatic relapses were not studied.

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