Haemolytic anaemia with acanthocytosis and erythrocytic glutathione peroxidase deficiency in severe hepatic diseases. 5 cases
Najman, A.; Fraitag, B.; Puget, K.; Lichtenstein, H.; Bodin, P.; Gorin, N.C.; Michelson, A.M.; Conte, M.; Duhamel, G.
La Nouvelle Presse Medicale 9(3): 161-165
1980
ISSN/ISBN: 0301-1518 PMID: 7355097 Document Number: 166414
In 5 patients, haemolysis was intrasplenic. Red cell deformity could be acquired by foreign red cells transfused into the patient. Association of the two abnormalities (acanthocytosis and glutathion peroxydase deficiency) was necessary for the onset of haemolysis. They progressed in parallel and varied in relation with the severity of the hepatic disease. The relationship between these two abnormalities is unknown but would appear to be dependent upon a factor of hepatic origin.