Action of levorin on glucose transport in the rat small intestine
Roshchina, G.M.; Lishnevskaia, E.B.; Sizova, I.A.; Orlova, V.A.; Tereshin, I.M.
Antibiotiki 25(11): 850-854
1980
ISSN/ISBN: 0003-5637 PMID: 7447401 Document Number: 165753
The technique of accumulating preparation of the mucosa and "turned out sac" was used to show that levorin, a polyenic antibiotic in a concentration of 10(-6) M, lowered the transport rate and accumulation of glucose by the epithelial cells of the rat thin intestine under conditions of oxygenation. Suppression of the glucose transport in the first stages resulted in partial inhibition of the transmembrane transfer. It is suggested that levorin suppression of the glucose transport through the erythrocyte apical membrane in the thin intestine is associated with a decrease in the electrochemical gradient of Na+.