Conjugation of polyamines in mammalian cells in culture
Melvin, M.A.; Wallace, H.M.; Keir, H.M.
Physiological Chemistry and Physics 12(5): 431-439
1980
ISSN/ISBN: 0031-9325 PMID: 7208639 Document Number: 165242
In cultures of BHK-21/C13 cells (Syrian baby hamster kidney fibroblasts) or 3T6 cells (Swiss mouse embryonic fibroblasts), spermidine and spermine undergo conjugation to a low molecular weight moiety which, under certain conditions, is excreted from cells into the extracellular fluid. A schematic model has been devised to describe the various metabolic processes that may be involved in the control of polyamine levels in mammalian cells and their extracellular fluid.