Functional role of noradrenergic neurons in the hypothermic effect of apomorphine and other dopaminomimetics
Shchelkunov, E.L.; Andreeva, O.G.; Korovin, K.F.; Ostroumova, M.N.
Farmakologiia i Toksikologiia 43(5): 558-563
1980
ISSN/ISBN: 0014-8318 PMID: 7449984 Document Number: 165170
Administration of 6-hydroxydopamine hydrobromide (20-50 mg) into the cerebral ventricles of mice products the depletion of noradrenaline and dopamine in the brain and counteracts the hypothermic effect of dopaminomimetic drugs of direct (apomorphine, piribedil, bromocryptin, CM29-712) and indirect (d, l-amphetamine, L-DOPA) type of action. Pretreatment of animals with the blockers of catecholamines noradrenergic neuronal uptake (desipramine, protryptyline and AW15(1)II29) counteracts both the depletion of noradrenaline in the brain and the antihypothermic effect of 6-hydroxydopamine. The experimental data support the noradrenergic involvement in the hypothermic effect of dopaminomimetics in mice.