Determination of free pentachlorophenol in air and in blood by efficient chromatographic procedures
Woiwode, W.; Wodarz, R.; Drysch, K.; Weichardt, H.
International Archives of Occupational and Environmental Health 45(2): 153-161
1980
ISSN/ISBN: 0340-0131 PMID: 7364491 Document Number: 164707
Efficient chromatographic procedures for the determination of free pentachlorophenol in air and in blood were developed. Free pentachlorophenol from the indoor environment is preconcentrated in an impinger. Following a simple extraction, it is detected by high performance liquid chromatography without derivatization. An alternate method is capillary gas chromatography of a suitable derivative. Unchanged pentachlorophenol in whole blood is similarly derivatized and quantitatively determined by capillary gas chromatography using an electron capture detector. The calibration curves of the described chromatographic methods were linear within the specified concentration range. Reproducibility of gas chromatographic separation remained unchanged during the whole research period. Due to its relative simplicity, the described gas chromatographic method is advantageous for the biological monitoring of large collectives.