Renal tubular acidification in patients treated with anticonvulsants
González Macías, J.; Rodríguez Commes, J.L.; de Manueles Jiménez, J.; Tabernero Romo, J.M.; de Castro del Pozo, S.
Medicina Clinica 74(8): 309-311
1980
ISSN/ISBN: 0025-7753 PMID: 7374234 Document Number: 164660
Proximal and distal renal tubular acidification function has been studied in ten epileptics treated with phenobarbital and hydantoins. Plasma concentration of 25 OH D3 and urinary excretion of adenosine 3':5'-cyclic phosphate (cAMP) were also determined. Serum parathormone (PTH) was analyzed in five patients. Four of these ten patients showed a decreasing threshold for bicarbonates, suggesting a disturbance of the proximal tubular acidification function. These patients did not show diminishing plasma levels of 25 OH D3, and according to the results of cAMP and PTH determinations a hyperparathyroidism could be ruled out. Anticonvulsants lead to a disturbance of the renal acidification which is not derived from alterations of the phosphocalcic metabolism.