Cardiovascular responses of the rat to a prostaglandin endoperoxide analog
Damas, J.; Troquet, J.; Barac, G.
Comptes Rendus des Seances de la Societe de Biologie et de ses Filiales 173(6): 1163-1169
1980
ISSN/ISBN: 0037-9026 PMID: 6446370 Document Number: 164612
In the anaesthetized rat, injection of the prostaglandin endoperoxide analog, U 44069, in the right ventricle is vasopressor both in the pulmonary and the systemic circulation. When a moderate dose is used, the hypertensive response of the systemic vascular bed changes in an hypotension. The toxicity seems to be cumulative. At high doses, a vascular collapse is observed sometimes with pulmonary oedema. These findings correlate with the EKG pattern typical for an acute cor pulmonale.