What Lies Beneath the Face Value of a BOX WARNING: a Deeper look at Brodalumab
Hashim, P.W.; Chen, T.; Lebwohl, M.G.; Marangell, L.B.; Kircik, L.H.
Journal of Drugs in Dermatology Jdd 17(8): S29-S34
2018
ISSN/ISBN: 1545-9616 PMID: 30124737 Document Number: 16375
Brodalumab, a fully human antibody of the interleukin-17 receptor, is highly effective in the treatment of moderate-to-severe plaque psoriasis. However, based on safety signals identified in clinical trials, brodalumab carries a boxed warning regarding possible risks of suicidal ideation and behavior (SIB). The validity of this link remains controversial, especially in the context of the psoriasis population as well as clinical trial data from other recently approved treatments. Herein, we critically examine the association between brodalumab and SIB.
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