Ultrastructural changes in the undamaged areas of the myocardium in rats with ischaemic-metabolic cardiomyopathy
Zlatewa, M.; Angelow, A.
Zentralblatt für Allgemeine Pathologie U. Pathologische Anatomie 124(1-2): 136-144
1980
ISSN/ISBN: 0044-4030 PMID: 7415597 Document Number: 163571
The ultrastructural changes in the undamaged areas of the myocardium in rats with ischemic-metabolic cardiomyopathy induced by treatment with Na2HPO4, Sopolcort H, and adrenalin are studied. In the cardiac muscle cells that seem to be uninjured, by light-microscopic investigation considerable damages of the mitochondria, sarcoplasmatic reticulum, myofibrils and the intercalated discs are found. These damages show that the there are a heavy hypoxia and metabolic disturbances outside the infarcted zones. Probably, they have certain significance for the progression of the morbid process in the myocardium.