The toxic and teratogenic effect of aflatoxin B1 on the chick embryo development
Cilievici, O.; Cordos, I.; Ghiduş, E.; Moldovan, A.
Morphologie et Embryologie 26(4): 309-314
1980
ISSN/ISBN: 0377-5038 PMID: 6450879 Document Number: 163446
The embryotoxic and teratogenic effect of aflatoxin B1 was tested on the chick embryo. Aflatoxin B1 was injected into the embryonic area in doses of 1/100 ppm and 1/500 ppm in the 96th h of incubation. Aflatoxin B1 toxicity caused a rise in the mortality rate from 6.6% (controls) to 35% in the chicken injected with 1/100 ppm aflatoxin B1 and to 26% in the lot given 1/500 ppm. Several malformations were also noticed: spina bifida, anophthalmia, maxillary retrognathism, distorted legs and evisceration; the group receiving 1/100 ppm aflatoxin B1 also showed bone development retardation of the wing, leg, maxilla and mandible.