Effect of acetylcholine on cyclic guanosine monophosphate levels in the hearts of rats of different ages
Kul'chitskiĭ, O.K.
Biulleten' Eksperimental'noi Biologii i Meditsiny 90(9): 318-319
1980
ISSN/ISBN: 0365-9615 PMID: 6252989 Document Number: 163247
The effect of various doses of acetylcholine on the content of myocardial cGMP was studied in rats of different age. The degree of changes was shown to depend on acetylcholine dosage and animals' age. Low doses produced more potent effect in adult rats. It is suggested that these features of alteration of cGMP content may be a reason for increased myocardial sensitivity to acetylcholine in old age.
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