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Results of clinical application of methods of individual selection of chemotherapeutic preparations in the treatment of gliomas

Apshkalne, D.L.; Kruminia, G.A.; Kikut, R.P.; Kotel'nikov, V.M.

Zhurnal Voprosy Neirokhirurgii Imeni N. N. Burdenko 1980(6): 7-12

1980

ISSN/ISBN: 0042-8817
PMID: 6258363
Document Number: 162734
The method of autoradiography for testing the efficacy of cytostatics with subsequent individually chosen chemotherapy is one of the components of rational therapy for neuro-oncological patients. Purposeful chemotherapy was applied in 17 cases with gliomas. Favourable results were recorded in 70.6% of them. Twelve patients received regular courses of treatment with one agent which inhibited DNA synthesis in vitro most potently (in 7 the therapeutic result was favourable), 5 patients were given course of polychemotherapy (favourable effect in 100%). Prolonged survival and a good remission allow autoradiography to be recommended as a method for the individual choice of antiblastic agents.

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