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Plasma estriol in the evaluation of third-trimester gestational age

Johnson, T.R.; Compton, A.A.; Kirkish, L.S.; Bozynski, M.E.; Barclay, M.L.; McCann, D.S.

Obstetrics and Gynecology 55(5): 621-624

1980

ISSN/ISBN: 0029-7844
PMID: 7366921
Document Number: 162543
This study attempts to confirm previous reports of a clinically useful serum unconjugated estriol surge at 36 weeks' gestation. Although an apparently physiologic estriol surge occurred at 36 +/- 2.1 weeks in 25 of 32 patients, clinical reality makes weekly plasma sampling difficult. In individual cases, use of the "surge point" predicted gestational age within a 4-week range with only 66% accuracy, and potentially serious errors in dating occurred. Other biochemical (lecithin:sphingomyelin, phosphatidylglycerol) and sonographic methods are superior in resolving problems with dating gestational age in the third trimester.

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