Maternal serum 25-hydroxy vitamin D levels in the first trimester and adverse gestational outcomes
Álvarez-Silvares, E.; Vilouta-Romero, M.; Borrajo-Hernández, E.; Morales-Serrano, M.L.; Alves-Pérez, M.T.
Ginecologia y Obstetricia de Mexico 84(3): 150-163
2016
ISSN/ISBN: 0300-9041 PMID: 27424441 Document Number: 687756
Some disorders of pregnancy and newborn have been associated with vitamin D deficiency (25 (OH) D) in maternal serum. The pathophysiology of this relationship is unknown today. The aim of this study was to determine whether serum levels of vitamin D at the beginning of pregnancy are associated with gestational diabetes, hypertensive disorders of pregnancy, preterm birth and fetal growth restriction. We conducted a prospective cohort study in 370 pregnant women at low obstetric risk randomly selected in our area (latitude 42 ° 20'N). The level of 25-hydroxy vitamin D was determinate between 8 and 14 weeks of pregnancy. We studied the relationship between the status of vitamin D and gestational diabetes, preeclampsia, preterm birth, intrauterine growth restriction and small for gestational age. The statistic analysis was performed using SPSS 15.0 and 3.1 Epidat programs. The prevalence of vitamin D deficiency in pregnant women in this serie was 96.8%, 34.6% had severe deficiency. After adjusting for maternal and seasonal variables, we haven't found association between first trimester maternal serum vitamin D levels and pregnancy outcomes studied. The pregnancy outcome was independent of the first trimester maternal serum 25(OH)D status.