Secretory mechanism of intragastric gastrin in man
Hengels, K.J.; Scholten, T.; Müller, J.E.; Fritsch, W.P.
Zeitschrift für Gastroenterologie 18(4): 181-184
1980
ISSN/ISBN: 0044-2771 PMID: 7424071 Document Number: 161922
Gastric acid secretion and gastrin-like immunoreactivity in serum and gastric juice of six healthy subjects were measured during an increasing intravenous administration of pentagastrin and compared with basal values obtained during intravenous infusion of 0.9% NaCl. Gastric acid secretion and gastrin-like immunoreactivity in the serum increased significantly during infusion of pentagastrin. Gastrin-like immunoreactivity released into the gastric lumen was unchanged from the NaCl control. This is a further evidence for direct secretion of gastrin into the lumen of the stomach from antral G-cells.