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Protective properties of antigenic preparations of Pseudomonas aeruginosa

Grishina, I.A.; Kolker, I.I.; Stanislavskiĭ, E.S.; Zhvanetskaia, M.I.; Palkina, M.I.

Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 6: 63-67

1980

ISSN/ISBN: 0372-9311
PMID: 6778029
Document Number: 161814
The protective activity of various Ps. aeruginosa cell antigens was studied, with the aim of isolating highly active components for a complex immunologic preparation against Ps. aeruginosa infection. The preparations of the supernatant fluid obtained by ultracentrifugation of slime or aqueous extract of Ps. aeruginosa were found to have the highest protective activity. Such preparations had low toxicity. Antigens with a molecular weight of 10,000 to 30,000 daltons obtained by the membrane fractionation of the aqueous extracts of acetone-treated bacteria, had also a high protective activity and were non-toxic for rats.

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