The 5-hydroxytryptamine take-up mechanism in normal platelets and platelets from migraine and asthmatic patients
Malmgren, R.; Olsson, P.; Tornling, G.; Unge, G.
Thrombosis Research 18(5): 733-741
1980
ISSN/ISBN: 0049-3848 PMID: 7414559 Document Number: 161629
The initial velocity for 5-HT take-up by platelets was studied in platelet rich plasma from healthy blood donors and patients with migraine or asthma. The kinetic data were analyzed according to Lineweaver-Burk and Eadie-Hofstee. The latter plot revealed only one machanism for active transport of 5-HT through the outer membrane of the normal platelet. In most of the patients no distinct curves depicting a plain active take-up mechanism could be detected. The findings indicate that 5-HT clearance may be severely disturbed in migraine and asthmatic patients.