Biotransformation and excretion of methylcyclopentadienyl manganese tricarbonyl in the rat
Hanzlik, R.P.; Bhatia, P.; Stitt, R.; Traiger, G.J.
Drug Metabolism and Disposition the Biological Fate of Chemicals 8(6): 428-433
1980
ISSN/ISBN: 0090-9556 PMID: 6109612 Document Number: 161617
The biotransformation and excretion of methylcyclopentadienyl manganese tricarbonyl (MMT) has been studied in vivo in the rat, and in vitro by using rat liver and lung microsomes. Orally administered 3H-MMT is efficiently absorbed, metabolized, and excreted in the urine as two major metabolites, (CO)3MnC5H4CO2H and (CO)3MnC5H4CH2OH, which account for 67% and 14% of the urinary tritium, respectively. There metabolites are also excreted in significant quantities in bile, but undergo reabsorption and excretion by the kidney since only a small fraction of the administered tritium appears in the feces. In vitro MMT was rapidly metabolized by a cytochrome P-450-dependent process inducible in liver but not in lung microsomes. In vivo induction by phenobarbital doubles the rate of biliary excretion of MMT metabolites and confers a remarkable protection against the toxic effect of MMT.