Juvenile rheumatoid arthritis and HLA-B27
Mathon, G.; Paré, C.; Ménard, H.; Tétreault, L.; Camerlain, M.
Canadian Medical Association Journal 123(5): 377-379
1980
ISSN/ISBN: 0008-4409 PMID: 6973386 Document Number: 161217
Forty children with juvenile rheumatoid arthritis were studied to determine the frequency of the histocompatibility antigen HLA [human leukocyte antigen)-B27 in this disease and to characterize the arthropathy associated with this antigen. HLA-B27 was detected in four patients (10%). Its presence was associated in a statistically significant manner with sacroiliitis demonstrated radiologically and with a greater age at the time symptoms in the joints first appeared; this age was, on average, 10 years, compared with 6.29 years for the children without HLA-B27.