Viral Molecular Characterization of the First Congenital Rubella Syndrome Case in Vietnam
Tran, D.N.; Vu, M.P.; Ha, M.T.; Linh, T.Giang, P.; Komase, K.; Mizuguchi, M.; Ushijima, H.
Clinical Laboratory 57(5-6): 397-401
2011
ISSN/ISBN: 1433-6510 PMID: 21755831 Document Number: 16039
Background: Rubella virus (RV) infection during the first trimester of pregnancy often leads to severe birth defects known as congenital rubella syndrome (CRS). Methods: A premature newborn male was clinically diagnosed as CRS with cataracts, congenital heart defects, microcephaly, hepatosplenomegaly, and thrombocytopenia. The infection was confirmed serologically and molecularly. Results: The RV was characterized and clustered with the 2B genotype. Conclusions: The integrated description of clinical features, serological and molecular data provide a baseline for diagnosis and control of rubella and CRS in Vietnam. This is the first report of molecular investigation of wild-type RV strain in Vietnam, thus contributing to the documentation of RV's worldwide distribution.
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