Effect of exposure to stress on the role of T- and B-lymphocytes in the response of the hematopoietic system
Gorizontov, P.D.; Fedotova, M.I.; Belousova, O.I.; Khaitov, R.M.; Chermeneva, L.I.
Biulleten' Eksperimental'noi Biologii i Meditsiny 89(4): 415-417
1980
ISSN/ISBN: 0365-9615 PMID: 6966945 Document Number: 160167
Cellular composition of the bone marrow, spleen and peripheral blood was studied after 6-hour immobilization on the back in experiments on 4 groups of (CBAxC57BL)F1 mice with varying degree of T lymphocyte deficiency (thymectomy, sham thymectomy, administration of antilymphocytic serum, B mice). The evidence obtained shows that the "lymphoid peak" recorded in the bone marrow during stress is likely to be formed at the expense of T and B lymphocyte migration from the peripheral lymphoid organs. The data have been also obtained, indicating that T lymphocytes migrating to the bone marrow during the first 6-9 hours after the exposure to stress may participate in granulocytopoiesis activation.