Induction of a transplantable urinary bladder carcinoma in dogs
Harzmann, R.; Gericke, D.; Altenähr, E.; Bichler, K.H.
Investigative Urology 18(1): 24-28
1980
ISSN/ISBN: 0021-0005 PMID: 7410009 Document Number: 160142
An attempt was made to reduce the carcinoma induction latency period and to produce a transplantable urinary bladder cancer in dogs. After transurethral pellet application, 12 of 22 female beagles were given s.c. injections of aminodiphenyl, FANFT [2-formylamine-4-(5-nitro-2-furyl)-thiazole], or both. Monthly cytologic and histologic checks yielded the earliest evidence yet obtained for invasive urothelial urinary bladder carcinoma (15 mo.); 7 urothelial carcinomas of the urinary bladder and 3 of the renal pelvis were established. Tissue cultures of the urothelial carcinomas in vitro were successful. Transplantation of tumor cells to 23 nude mice resulted in tumor growth in 19. Transplantation to 10 beagles yielded 2 tumors very quickly, but the tumors were rejected within 4 wk.