Blood coagulability and heart activity on intravenous thrombin administration
Budazhapova, D.T.; Budazhabon, G.B.; Zagrebina, L.A.; Kuznik, B.I.; Mishchenko, V.P.
Kardiologiia 20(4): 83-86
1980
ISSN/ISBN: 0022-9040 PMID: 7374010 Document Number: 159474
It was shown in dog experiments that intravenous infusion of 30 and 70 U/kg of thrombin leads to the development of a short-term hypercoagulation phase which is replaced by long-term hypocoagulation and marked stimulation of fibrinolysis. An electrocardiogram provides evidence that after the infusion of 70 U/kg of thrombin acute ischemic disorders of coronary circulation develop in the dogs and remain for 3 days. The authors contend that the appearance of high doses of thrombin in the vascular channel is not a physiological reaction.