Effect of aprindine in patients with normal and pre-damaged impulse forming and excitation conducting system/First communication; Sinus node function
Pantlen, H.; Runge, M.; Luckmann, E.
Arzneimittel-Forschung 30(1): 92-95
1980
ISSN/ISBN: 0004-4172 PMID: 7370079 Document Number: 159192
In 18 patients the influence of aprindine on sinus node function has been evaluated. The criteria were heart rate in spontaneous rhythm, sinus node recovery time (SRT), and the warm-up period after atrial stimulation with frequencies between 90 and 140/min. After aprindine the spontaneous rate increased significantly, whereas SRT and the warm-up period were not affected significantly. The patients with sinu-atrial disease showed a shortening of the spontaneous cycle-length and a decrease in SRT after aprindine. The results are discussed regarding the electrophysiological characteristics of the sinus node (slow current, automaticity) and their changes produced by stimulation and aprindine.