Evaluation of chlorobenzene exposure on the basis of determination of 4-chlorocatechol in urine
Dutkiewicz, T.; Pacholuk, B.
Medycyna Pracy 31(4): 289-295
1980
ISSN/ISBN: 0465-5893 PMID: 7442536 Document Number: 158655
Both animal (rats) experiments and examinations of dyestuff industry workers exposed to chlorobenzene allowed to identify 4-chlorocatechol as one of the major chlorobenzene metabolites. 4-chlorocatecholuria was found to be monophasic with 24 h half-time, which indicates that concentrations are likely to increase in the body with everyday exposure. The 4-chlorocatechol test based on thin-layer chromatography and absorptiometry appeared to be fully useful for exposure evaluation and chlorobenzene poisonings diagnostics.