Treatment of severe psoriasis with ustekinumab during pregnancy
Andrulonis, R.; Ferris, L.K.
Journal of Drugs in Dermatology Jdd 11(10): 1240
2012
ISSN/ISBN: 1545-9616 PMID: 23134993 Document Number: 15833
We present the case of a female, aged 22 years, with a long history of recalcitrant pustular psoriasis and psoriatic arthritis, treated with ustekinumab during pregnancy. The result of treatment was an uncomplicated pregnancy with delivery, at term, of a healthy boy. To our knowledge, this is the first reported use of ustekinumab in a human during pregnancy. Following a description of the case, we discuss the characteristics of ustekinumab and review the known information from human case reports, case series, and animal studies regarding the use of TNF-a inhibitors and ustekinumab during pregnancy. We also provide a short discussion of administration of ustekinumab during the time period when a mother is nursing and the potential for complications to infants in this setting.
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