Regression on oxymetholone-induced hepatic tumors after bone marrow transplantation in aplastic anemia
Montgomery, R.R.; Ducore, J.M.; Githens, J.H.; August, C.S.; Johnson, M.L.
Transplantation 30(2): 90-96
1980
ISSN/ISBN: 0041-1337 PMID: 7010713 Document Number: 158082
Treatment of acquired aplastic anemia with androgens has been occasionally associated with the development of hepatic tumors. A 13 yr old boy with idiopathic aplastic anemia was studied in whom oxymetholone treatment was associated with a partial hematological remission. However, 34 mo. later the patient developed multiple hepatic tumors. When oxymetholone therapy was discontinued, the aplastic anemia relapsed. He then underwent bone marrow transplantation from his HLA-A B and D-compatible sibling. This was followed by hematological and immunological reconstitution. The hepatic tumors underwent progressive regression after bone marrow transplantation. The patient is now 3 yr post-bone marrow transplantation and is in complete remission of his aplastic anemia with no evidence of detectable liver tumors.